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The net loss for the third quarter of 2009 was $111,000, or break even on a per share basis, compared to a net loss of $1.5 million or $0.07 per share reported in the third quarter of 2008.

As of September 30, 2009, the company's cash, cash equivalents and short-term investments totaled $11.7 million, a net decrease of $400,000 from the $12.1 million reported December 31, 2008. Additionally, at September 30, 2009, NovaBay reported accounts receivable totaling approximately $1 million, primarily consisting of reimbursements from its partners Alcon and Galderma under its license and collaboration agreements. The company expects to receive payments related to these receivables in the fourth quarter. NovaBay also reported net proceeds of approximately $2 million from a registered direct offering completed during the quarter.

Research and development expenses for the quarter ending September 30 were $2.0 million, up from $1.6 million in the same quarter a year ago. The increased costs are attributed to an increase in clinical studies in 2009. General and administrative expenses for the third quarter of 2009 decreased to $1.3 million from $1.5 million a year ago. The decrease in costs occurred as a result of decreased headcount, and lower spending on Sarbanes-Oxley implementation.

"We continue to maintain a strong cash position, which has enabled us to make significant strides in our Aganocide(R) programs, both our proprietary candidates and those we are advancing with partners," said Ron Najafi, Ph.D, chairman and chief executive officer of NovaBay. "As multi-drug resistance to bacterial and fungal infections becomes an ever-increasing health crisis, NovaBay remains committed to developing a pipeline of potential products that do not potentiate resistance in bacteria and which can show equivalent or better performance than antibiotics. We bolstered our management team with several key hires this past quarter, and look forward to calling on their combined expertise as we look forward to 2010 and several important clinical milestones."

Nine Month Results

For the nine months ended September 30, 2009 net cash used in operating activities was $1.5 million, due to the receipt of milestone and other cash payments from collaborative agreements, which largely offset research and development, and general and administrative expenses.

NovaBay reported a net loss of $718,000 for the nine-month period ending September 30, down from a net loss of $6.6 million reported for the nine months ending in September 2008. Total license and collaboration revenue was $8.2 million for the nine months ended September 30, 2009 compared to $4.5 for the nine months ended September 30, 2008. The increase in revenue consisted almost exclusively of money earned under the license and collaboration agreements with Alcon and Galderma.

Total research and development expenses fell by 30 percent to $4.8 million for the nine months ended September 30, 2009 from $6.9 million for the nine months ended September 30, 2008. The decrease was primarily due to deferment of some clinical trials during the first half of 2009.

Total general and administrative expenses were $4.1 million for the nine months ended September 30, 2009, compared to $4.6 million for the nine months ended September 30, 2008. General and administrative expenses were lower overall because of lower head count and decreased expenditures on Sarbanes-Oxley implementation.

Third Quarter Highlights

--  Expanded and strengthened management team with the appointment of Roy
    Wu, as senior vice president of business development, and Mark Anderson,
    Ph.D., as chief scientific officer. Bez Khosrovi also assumed an expanded
    role as senior vice president for product development and chief alliance
    officer

--  Partner Alcon initiated a Phase 2 clinical trial of lead Aganocide
    compound NVC-422 for the treatment of viral conjunctivitis

--  Launched a Phase 2a proof-of-concept study of NVC-422 for the
    treatment of impetigo, one of the most common skin infections, with partner
    Galderma, S.A., the world's leading dermatology company

--  Presented positive data from two pre-clinical studies of NVC-422 at
    the 49th Annual Interscience Conference on Antimicrobial Agents and
    Chemotherapy conference, revealing that NVC-422 had potent activity in
    killing bacteria that have developed resistance to antiseptics and
    antibiotics

--  Presented data at the 47th Annual Meeting of the Infectious Diseases
    Society of America (IDSA) showing that NovaBay's Aganocide compounds
    demonstrated efficacy and penetration in an established pre-clinical
    infected nail model of onychomycosis, or nail fungus

--  Recognized as a New California 100 Innovative Business by Golden
    Capital Network and Hamilton Lane

Pipeline Overview

NovaBay also provided the following detailed pipeline overview of its most advanced partnered and proprietary development programs:

--  NovaBay and Alcon are currently conducting a Phase 2 clinical trial
    for the treatment of viral conjunctivitis, or "pink eye," at 30 centers
    around the U.S. in approximately 250 patients. The trial is expected to
    conclude in early 2010, with top-line data available in the first half of
    2010. NovaBay and its partner Alcon anticipate presenting complete Phase 2
    data at an appropriate medical meeting later in 2010. Conjunctivitis
    represents a potential $500 million to $1 billion market. While there are
    several antibiotics to treat the bacterial form of conjunctivitis, there
    are currently no medications to treat viral conjunctivitis. NovaBay's
    current formulation under development will have the potential to treat both
    bacterial and viral conjunctivitis. As part of the original NovaBay and
    Alcon collaboration, Alcon has paid NovaBay a $10 million upfront licensing
    fee and NovaBay may receive up to an additional $70 million in clinical
    milestones plus $20 million to support ongoing research and development
    efforts.

--  NovaBay and partner Galderma S.A. are conducting a Phase 2 clinical
    trial of NVC-422 in impetigo, a common skin condition that primarily
    affects children between the ages of 2 and 12. More than 1 million cases of
    impetigo are diagnosed annually in the United States alone. Top-line data
    is expected in the first half of 2010. As part of the NovaBay and Galderma
    collaboration signed in March 2009, NovaBay received a $2 million upfront
    payment. The company may receive up to $50 million in clinical milestones
    and R&D reimbursements.

--  NovaBay has initiated a Phase 2 trial of NVC-422 for the treatment of
    catheter-associated urinary tract infection (CAUTI). During the Phase 2
    trial, chronically catheterized patients with confirmed cases of
    bacteriuria receive a daily irrigation of bladder lavage to measure the
    extent to which NVC-422 can reduce the bacterial load, and therefore the
    incidence of CAUTI. CAUTI is the most common nosocomial (hospital-acquired)
    infection, responsible for nearly 40% of infections related to
    hospitalization. Top-line data from this trial is expected in the first
    half of 2010. A Phase 1 trial showed that NVC-422 was safe in healthy
    volunteers. In multiple pre-clinical studies, with Foley catheters, NVC-422
    solution demonstrated the ability to penetrate and eliminate the bacteria
    residing in biofilm. This is of particular importance in CAUTI, as biofilms
--  - which are complex colonies of microorganisms, proteins and other
    components -- form readily around catheters and often develop broad
    resistance to many commonly used antibiotics.

About NovaBay Pharmaceuticals, Inc.

NovaBay Pharmaceuticals is a clinical-stage biopharmaceutical company focused on developing its proprietary and patented Aganocide(R) compounds as first-in-class, novel, synthetic anti-infective product candidates that are bioequivalent to the active antimicrobial molecules generated within white blood cells to treat and prevent a wide range of infections without causing resistance.

NovaBay has internal development programs aimed at addressing hospital and respiratory infections. The company has a licensing and research collaboration agreement with Alcon, Inc. for use of its Aganocides in the eye, ear and sinus, and in contact lens solutions. NovaBay has entered into an agreement with Galderma S.A. to develop and commercialize Aganocides in acne, impetigo and other dermatological indications. NovaBay(TM) and Aganocide(R) are trademarks of NovaBay Pharmaceuticals, Inc. For more information on NovaBay, visit www.novabaypharma.com.

Forward-Looking Statements

This release contains forward-looking statements, which are based upon NovaBay's current expectations, assumptions, estimates, projections and beliefs. Statements regarding NovaBay's expectations that it will receive from Alcon up to $70 million in clinical milestones plus $20 million to support ongoing research and development efforts, and that it will receive from Galderma up to $50 million upon achievement of certain development and regulatory milestones, NovaBay's expectations regarding its clinical programs, including the timing of conclusions of those trials and when it will receive clinical data, as well as other statements that relate to future events or results, are forward-looking statements. Forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause actual results or achievements to be materially different and adverse from those expressed in or implied by the forward-looking statements. Factors that might cause or contribute to such differences include, but are not limited to: the risk that milestones and net sales may not be achieved under the Alcon and Galderma agreements; risks and uncertainties relating to difficulties or delays in discovery, development, testing, production and marketing of the company's product candidates; unexpected adverse side effects or inadequate therapeutic efficacy of the product candidates; the uncertainty of patent protection for the company's intellectual property or trade secrets; the company's ability to obtain additional financing as necessary; results obtained in animal models may not be obtained in humans; and the risk of unexpected delays in the regulatory process which may delay the commencement or completion of clinical trials. Other risks relating to NovaBay and Aganocide(R) compounds, including risks that could cause actual results to differ materially from those projected in the forward-looking statements in this press release, are detailed in NovaBay's Quarterly Report on Form 10-Q for the period ended September 30, 2009, under the caption "Risk Factors" in Item 1A of Part I of that report, filed with the Securities and Exchange Commission on November 12, 2009. The forward-looking statements in this release speak only as of this date, and NovaBay disclaims any intent or obligation to revise or update publicly any forward-looking statement except as required by law.

                                                                Cumulative
                                                               Period from
                                                               July 1, 2002
                                                                (date of
                                                               development
                                                                  stage
                 Three Months Ended      Nine Months Ended    inception) to
                   September 30,           September 30,      September 30,
               ----------------------  ---------------------- ------------
                  2008        2009        2008        2009        2009
               ----------  ----------  ----------  ---------- ------------
               (unaudited) (unaudited) (unaudited) (unaudited) (unaudited)
REVENUE
  License and
   collaboration
   revenue     $    1,592  $    3,224  $    4,526  $    8,192  $    22,360
EXPENSES
Operating
 Expenses:
  Research and
   development      1,614       2,004       6,861       4,809       29,816
  General and
   administra-
   tive             1,544       1,309       4,575       4,078       21,043
               ----------  ----------  ----------  ----------  -----------
  Total
   operating
   expenses         3,158       3,313      11,436       8,887       50,859
Interest
 expense              (28)        (56)        (77)        (98)        (244)
Other income
 (expense),
 net                  105          34         411          75        1,450
               ----------  ----------  ----------  ----------  -----------
Total Other
 income
 (expense), net        77         (22)        334         (23)       1,206
Net loss
 before income
 taxes             (1,489)       (111)     (6,576)       (718)     (27,293)
Provision for
 income taxes                       -           2                       14
               ----------  ----------  ----------  ----------  -----------
Net loss       $   (1,489) $     (111) $   (6,578) $     (718) $   (27,307)
               ==========  ==========  ==========  ==========  ===========
Net loss per
 share:
  Basic and
   diluted     $    (0.07) $    (0.00) $    (0.31) $    (0.03)
Shares used in
 per share
 calculations:
  Basic and
   diluted         21,443      23,251      21,313      22,117

Contact:
NovaBay Pharmaceuticals, Inc.
Tom Paulson
510-899-8809
Chief Financial Officer
tpaulson@novabaypharma.com

Media Relations:
Aimee Corso
503-855-4502
acorso@wcpglobal.com

SOURCE: NovaBay Pharmaceuticals

mailto:tpaulson@novabaypharma.com
mailto:acorso@wcpglobal.com

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SmarTrend analyzes over 5,000 securities simultaneously throughout the trading day and provides its subscribers with trend change alerts in real time. To get a free trial of our trading calls and maximize your trading results, please visit http://www.TradeTheTrend.com.

Get exclusive, actionable insight into how the market is expected to trend prior to market open with our free morning newsletter. Sign up at: http://www.TradeTheTrend.com/signup.html