In the Novartis-Alnylam collaboration, both companies are jointly responsible for RNAi discovery activities and Novartis is generally responsible for development and commercialization of RNAi therapeutic products. With the extension of the alliance term, Novartis will continue to fund collaboration research and development efforts conducted by Alnylam. Further, Novartis retains its right to exercise a non-exclusive platform license from Alnylam in exchange for an undisclosed payment and future milestones and royalties. In addition, Novartis has the option to extend the collaboration for one additional one-year term through 2010. Finally, Novartis retains certain rights to purchase Alnylam equity up to 19.9%; current Novartis ownership is approximately 13.4%.

About RNA Interference (RNAi)

RNAi (RNA interference) is a revolution in biology, representing a breakthrough in understanding how genes are turned on and off in cells, and a completely new approach to drug discovery and development. Its discovery has been heralded as "a major scientific breakthrough that happens once every decade or so," and represents one of the most promising and rapidly advancing frontiers in biology and drug discovery today which was awarded the 2006 Nobel Prize for Physiology or Medicine. RNAi is a natural process of gene silencing that occurs in organisms ranging from plants to mammals. By harnessing the natural biological process of RNAi occurring in our cells, the creation of a major new class of medicines, known as RNAi therapeutics, is on the horizon. RNAi therapeutics target the cause of diseases by potently silencing specific messenger RNAs (mRNAs), thereby preventing disease-causing proteins from being made. RNAi therapeutics have the potential to treat disease and help patients in a fundamentally new way.

About Alnylam Pharmaceuticals

Alnylam is a biopharmaceutical company developing novel therapeutics based on RNA interference, or RNAi. The company is applying its therapeutic expertise in RNAi to address significant medical needs, many of which cannot effectively be addressed with small molecules or antibodies, the current major classes of drugs. Alnylam is leading the translation of RNAi as a new class of innovative medicines with peer-reviewed research efforts published in the world's top scientific journals including Nature, Nature Medicine, and Cell. The company is leveraging these capabilities to build a broad pipeline of RNAi therapeutics; its most advanced program is in Phase II human clinical trials for the treatment of respiratory syncytial virus (RSV) infection. In addition, the company is developing RNAi therapeutics for the treatment of a wide range of disease areas, including hypercholesterolemia, liver cancers, and Huntington's disease. The company's leadership position in fundamental patents, technology, and know-how relating to RNAi has enabled it to form major alliances with leading companies including Medtronic, Novartis, Biogen Idec, Roche, Takeda, and Kyowa Hakko Kogyo. To reflect its outlook for key scientific, clinical, and business initiatives, Alnylam has established "RNAi 2010" which includes the company's plan to significantly expand the scope of delivery solutions for RNAi therapeutics, have four or more programs in clinical development, and to form four or more new major business collaborations, all by the end of 2010. Alnylam is a joint owner of Regulus Therapeutics LLC, a joint venture focused on the discovery, development, and commercialization of microRNA therapeutics. Founded in 2002, Alnylam maintains headquarters in Cambridge, Massachusetts. For more information, visit www.alnylam.com.

Alnylam Forward-Looking Statements

Various statements in this release concerning Alnylam's future expectations, plans and prospects, constitute forward-looking statements for the purposes of the safe harbor provisions under The Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors, including risks related to: Alnylam's approach to discover and develop novel drugs, which is unproven and may never lead to marketable products; obtaining, maintaining and protecting intellectual property; Alnylam's ability to enforce its patents against infringers and to defend its patent portfolio against challenges from third parties; Alnylam's ability to obtain additional funding to support its business activities; Alnylam's ability to realize future milestones and royalties; Alnylam's dependence on third parties for development, manufacture, marketing, sales and distribution of products; obtaining regulatory approval for products; competition from others using technology similar to Alnylam's and others developing products for similar uses; Alnylam's dependence on collaborators; and Alnylam's short operating history; as well as those risks more fully discussed in the "Risk Factors" section of its most recent quarterly report on Form 10-Q on file with the Securities and Exchange Commission. In addition, any forward-looking statements represent Alnylam's views only as of today and should not be relied upon as representing its views as of any subsequent date. Alnylam does not assume any obligation to update any forward-looking statements.

SOURCE: Alnylam Pharmaceuticals, Inc.

Alnylam Pharmaceuticals, Inc.
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*Novartis expects Menveo to be first quadrivalent meningococcal vaccine to protect from early infancy through adulthood

*More than 8 million infants and adolescents in the US and a significant number of children and travellers globally could benefit from Menveo[1]

Basel, May 6, 2008 - New Phase III data for Menveo(R) (MenACWY-CRM) show that the vaccine produced a greater immune response against meningococcal serogroups A, C, W-135 and Y in adolescents 11-18 years of age compared to Menactra(R). Infection with any of these four vaccine-preventable serogroups can lead to bacterial meningitis, an infection of the membrane around the brain and spinal cord, or sepsis, a serious infection of the blood stream. Results of this first head-to-head trial of Menveo compared to Menactra, show that adolescents who were immunized with Menveo generated higher levels of antibodies against all four serogroups[2]. Notably for serogroup Y, among adolescents with low levels of immunity at the time of vaccination, 81% of subjects receiving Menveo generated a protective immune response vs. 54% with Menactra[2], as measured by the hSBA assay. Serogroup Y causes approximately 39% of meningococcal disease cases in the US[3]. "To protect children against all major serogroups of meningococcal disease, we need vaccines that provide broad coverage and that can be used in all at-risk age groups," said Keith S. Reisinger, MD, MPH, Medical Director, Primary Physicians Research, Inc. Pittsburgh, PA. "These data are encouraging because they show that Menveo may provide greater protection for the more than 8 million infants and adolescents in the US against these four vaccine-preventable serogroups than the currently available vaccine." Menveo is an investigational quadrivalent meningococcal conjugate vaccine in Phase III clinical development by Novartis Vaccines. The data were presented at a late-breaker platform session on May 5 during the 2008 Pediatric Academic Societies (PAS) Annual Meeting in Honolulu, Hawaii. Meningococcal disease, a leading cause of bacterial meningitis, is a rare but contagious and potentially life-threatening infection. Infants and adolescents have the highest rates of disease[4a], which can be fatal. Each year approximately 1,400 to 2,800 cases of disease occur in the US[4b], and about 10-14 percent of patients die[4c]. The currently available vaccines are not licensed for use in infants, in whom the highest rates of meningococcal disease are observed. Phase II data published in the January 9, 2008, issue of the Journal of the American Medical Association demonstrated Menveo to be the first meningococcal vaccine to produce a strong immune response in infants[5]. The US Centers for Disease Control and Prevention (CDC) recommends routine immunization with a quadrivalent meningococcal conjugate vaccine for all adolescents 11-18 years of age, college freshmen living in dormitories and people in other high risk groups who are two to ten or 19 to 55 years of age[6,7]. "The patient need for vaccines for meningococcal disease remains substantial. We appear to be quickly realizing our goal of providing broad coverage against all serogroups of meningococcal disease across all age groups," said Joerg Reinhardt, CEO of Novartis Vaccines and Diagnostics. "Given the broad range of age groups this vaccine is expected to protect, Menveo could truly fulfill an unmet need in the meningitis vaccine market." Study details[2] This Phase III trial involved more than 2,100 11-18 year olds who received a single vaccination with either Menveo or Menactra. One month after vaccination, geometric mean titers (a measure of immune response) for Menveo vs. Menactra were: serogroup A, 29 vs. 18; serogroup C, 59 vs. 47; serogroup W-135, 87 vs. 44; and serogroup Y, 51 vs. 18. Additionally, the percentage of participants who achieved a protective immune response, determined by a human serum bactericidal antibody titer (hSBA) > 1:8, with Menveo vs. Menactra was: serogroup A, 75% vs. 67%; serogroup C, 84% vs. 84%; serogroup W-135, 96% vs 88%; and serogroup Y, 88% vs. 69%. Similar results were seen in the large subset of sero-negative participants, who are the participants without any natural immunity to the bacteria before vaccination. The hSBA assay measures the body's protective immune response to the meningococcus based on the ability of antibodies to kill the bacteria. About Menveo These data build on previous studies that demonstrated Menveo generates a strong protective immune response against these four vaccine-preventable serogroups in people across age groups from infancy to adulthood. Novartis expects to submit a Biologics License Application (BLA) to the US Food and Drug Administration later this year. Menveo is currently in multiple Phase III clinical trials involving infants, young children, adolescents and adults. The vaccine is based on the same technology Novartis pioneered to produce Menjugate(R), a meningococcal serogroup C conjugate vaccine approved outside the US since 2000 for use in individuals from two months of age through adulthood. Novartis is a global leader in providing vaccines to protect against the deadly meningococcal disease. In addition to developing Menveo, Novartis has already distributed more than 26 million doses of Menjugate around the world and produced MenZB(R), a vaccine against a strain of meningococcus B specific to a recent outbreak in New Zealand. Novartis is also developing a recombinant vaccine to provide broad coverage against multiple strains of serogroup B, for which no vaccine is currently available. About meningococcal disease, a leading cause of bacterial meningitis Meningococcal disease can manifest as bacterial meningitis - an infection of the membranes around the brain and spinal cord - or sepsis, a bloodstream infection. It is caused by the bacterium Neisseria meningitidis (N. meningitidis). The symptoms - which can include sudden onset of fever, rash, headache, and stiff neck - can progress rapidly. Even with early and appropriate treatment, some cases are fatal[4b], typically within 24-48 hours[8]. For those who survive, as many as 19 percent suffer serious long-term consequences such as deafness, neurological damage or limb loss[4d]. Disclaimer The foregoing release contains forward-looking statements that can be identified by terminology such as "may", "expects", and "encouraging", "potentially", "can be", "goal", "expected", or similar expressions, or by express or implied discussions regarding potential future regulatory filings or approvals for, or potential future sales of, Menveo or other vaccines currently in development by Novartis. Such forward-looking statements reflect the current views of Novartis regarding future events, and involve known and unknown risks, uncertainties and other factors that may cause actual results with Menveo to be materially different from any future results, performance or achievements expressed or implied by such statements. There can be no guarantee that Menveo or any other vaccine currently in development by Novartis will be submitted or approved for any indications in any market. Nor can there be any guarantee that Menveo or any other vaccine, if approved, will achieve any particular levels of sales. In particular, management's expectations regarding Menveo could be affected by, among other things, unexpected clinical trial results, including unexpected new clinical data and unexpected additional analysis of existing clinical data; unexpected regulatory actions or delays or government regulation generally; Novartis' ability to obtain or maintain patent or other proprietary intellectual property protection; competition in general; government, industry and general public pricing pressures, and other risks and factors referred to in Novartis AG's Form 20-F on file with the U.S. Securities and Exchange Commission. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those anticipated, believed, estimated or expected. Novartis is providing the information in this press release as of this date and does not undertake any obligation to update any forward-looking statements contained in this press release as a result of new information, future events or otherwise. About Novartis Novartis Vaccines and Diagnostics is a division of Novartis focused on the development of preventive treatments. The division has two businesses: Novartis Vaccines and Chiron. Novartis Vaccines is the world's fifth-largest vaccines manufacturer and second-largest supplier of flu vaccines in the US. The division's products include influenza, meningococcal, pediatric and travel vaccines. Chiron, the blood testing and molecular diagnostics business, is dedicated to preventing the spread of infectious diseases through the development of novel blood-screening tools that protect the world's blood supply. Novartis AG provides healthcare solutions that address the evolving needs of patients and societies. Focused on growth areas in healthcare, Novartis offers a diversified portfolio to best meet these needs: innovative medicines, cost-saving generic pharmaceuticals, preventive vaccines and diagnostic tools, and consumer health products. Novartis is the only company with leading positions in these areas. In 2007, the Group's continuing operations (excluding divestments in 2007) achieved net sales of USD 38.1 billion and net income of USD 6.5 billion. Approximately USD 6.4 billion was invested in R&D activities throughout the Group. Headquartered in Basel, Switzerland, Novartis Group companies employ approximately 98,000 full-time associates and operate in over 140 countries around the world. For more information, please visit http://www.novartis.com. References [1]Novartis Vaccines and Diagnostics Earnings Presentations. Growth Through Innovation. January 17, 2008. [2] Jackson L, et al. A Phase III study comparing the safety and immunogenicity of a novel qualdrivalent meningococcal conjugate vaccine, MenACWY-CRM, with the licensed MCV4, Menactra(R) in adolescents. Abstract # 5628.8, 2008 Pediatric Academic Society Annual Meeting, Honolulu, HI. [3] Centers for Disease Control and Prevention. Active Bacterial Core Surveillance Report, Emerging Infections Program Network, Neisseria meningitidis, 2006. Available at: http://www.cdc.gov/ncidod/dbmd/abcs/survreports/mening06.pdf [4] U.S. Centers for Disease Control. Fact Sheet: Meningococcal Disease and Meningococcal Vaccines (April 25, 2006). Available at: http://www.cdc.gov/vaccines/vpd-vac/mening/vac-mening-fs.htm [5]Snape, MD et al. Immunogenicity of a Tetravalent Meningococcal Glycoconjugate Vaccine in Infants: A Randomized Controlled Trial. Journal of the American Medical Association. 2008; 299(2):173-184 [6] Centers for Disease Control and Prevention. Revised recommendations of the Advisory Committee on Immunization Practices to vaccinate all persons aged 11--18 years with meningococcal conjugate vaccine. MMWR 2007;56:794--795. [7] Centers for Disease Control and Prevention. Notice to readers: Recommendations from the Advisory committee on Immunization Practices for use of quadrivalent meningococcal conjugate vaccine (MCV4) in children aged 2-10 years at increased risk for invasive meningococcal disease. MMWR. 2007;56(48):1265-1266. [8] WHO.Meningococcal meningitis Fact sheet #141.May 2003. http://www.who.int/mediacentre/factsheets/fs141/en/ * Menactra is a registered trademark of Sanofi Pasteur. # # # Novartis Media Relations

Beatrix Benz Beth Birke Novartis Global Media Novartis Vaccines and Diagnostics Relations +1 (617) 871 4281 (direct) +41 61 324 7999 (direct) +1 (617) 803 4359 (mobile) +41 79 618 7748 (mobile) nvd.communications@novartis.com media.relations@novartis.com

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SOURCE: Novartis International AG

Infection with any of the serogroups can lead to bacterial meningitis.

Menveo is currently in multiple Phase III clinical trials involving infants, young children, adolescents and adults.

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Notably for serogroup Y, among adolescents with low levels of immunity at the time of vaccination, 81% of subjects receiving Menveo generated a protective immune response vs. 54% with Menactra, as measured by the hSBA assay. Serogroup Y causes approximately 39% of meningococcal disease cases in the US.

"To protect children against all major serogroups of meningococcal disease, we need vaccines that provide broad coverage and that can be used in all at-risk age groups," said Keith S. Reisinger, MD, MPH, Medical Director, Primary Physicians Research, Inc. Pittsburgh, PA. "These data are encouraging because they show that Menveo may provide greater protection for the more than 8 million infants and adolescents in the US against these four vaccine-preventable serogroups than the currently available vaccine."

Menveo is an investigational quadrivalent meningococcal conjugate vaccine in Phase III clinical development by Novartis Vaccines. The data were presented at a late-breaker platform session on May 5 during the 2008 Pediatric Academic Societies (PAS) Annual Meeting in Honolulu, Hawaii.

Meningococcal disease, a leading cause of bacterial meningitis, is a rare but contagious and potentially life-threatening infection. Infants and adolescents have the highest rates of disease, which can be fatal. Each year approximately 1,400 to 2,800 cases of disease occur in the US, and about 10-14 percent of patients die. The currently available vaccines are not licensed for use in infants, in whom the highest rates of meningococcal disease are observed. Phase II data published in the January 9, 2008, issue of the Journal of the American Medical Association demonstrated Menveo to be the first meningococcal vaccine to produce a strong immune response in infants.

The US Centers for Disease Control and Prevention (CDC) recommends routine immunization with a quadrivalent meningococcal conjugate vaccine for all adolescents 11-18 years of age, college freshmen living in dormitories and people in other high risk groups who are two to ten or 19-55 years of age.

"The patient need for vaccines for meningococcal disease remains substantial. We are quickly realizing our goal of providing broad coverage against all serogroups of meningococcal disease across all age groups," said Joerg Reinhardt, CEO of Novartis Vaccines and Diagnostics. "Given the broad range of age groups this vaccine is expected to protect, Menveo could truly fulfill an unmet need in the meningitis vaccine market."

Study details

This Phase III trial involved more than 2,100 11-18 year olds who received a single vaccination with either Menveo or Menactra. One month after vaccination, geometric mean titers (a measure of immune response) for Menveo vs. Menactra were: serogroup A, 29 vs. 18; serogroup C, 59 vs. 47; serogroup W-135, 87 vs. 44; and serogroup Y, 51 vs. 18. Additionally, the percentage of participants who achieved a protective immune response, determined by a human serum bactericidal antibody titer (hSBA) greater than or equal to 1:8, with Menveo vs. Menactra was: serogroup A, 75% vs. 67%; serogroup C, 84% vs. 84%; serogroup W-135, 96% vs 88%; and serogroup Y, 88% vs. 69%. Similar results were seen in the large subset of sero-negative participants, who are the participants without any natural immunity to the bacteria before vaccination. The hSBA assay measures the body's protective immune response to the meningococcus based on the ability of antibodies to kill the bacteria.

About Menveo

These data build on previous studies that demonstrated Menveo generates a strong protective immune response against these four vaccine-preventable serogroups in people across age groups from infancy to adulthood. Novartis expects to submit a Biologics License Application (BLA) to the US Food and Drug Administration later this year.

Menveo is currently in multiple Phase III clinical trials involving infants, young children, adolescents and adults. The vaccine is based on the same technology Novartis pioneered to produce Menjugate(R), a meningococcal serogroup C conjugate vaccine approved outside the US since 2000 for use in individuals from two months of age through adulthood.

Novartis is a global leader in providing vaccines to protect against the deadly meningococcal disease. In addition to developing Menveo, Novartis has already distributed more than 26 million doses of Menjugate around the world and produced MenZB(R), a vaccine against a strain of meningococcus B specific to a recent outbreak in New Zealand. Novartis is also developing a recombinant vaccine to provide broad coverage against multiple strains of serogroup B, for which no vaccine is currently available.

About meningococcal disease, a leading cause of bacterial meningitis

Meningococcal disease can manifest as bacterial meningitis -- an infection of the membranes around the brain and spinal cord -- or sepsis, a bloodstream infection. It is caused by the bacterium Neisseria meningitidis (N. meningitidis). The symptoms -- which can include sudden onset of fever, rash, headache, and stiff neck -- can progress rapidly. Even with early and appropriate treatment, some cases are fatal, typically within 24-48 hours. For those who survive, as many as 19 percent suffer serious long-term consequences such as deafness, neurological damage or limb loss.

Disclaimer

The foregoing release contains forward-looking statements that can be identified by terminology such as "may", "expects", and "encouraging", "potentially", "can be", "goal", "expected", or similar expressions, or by express or implied discussions regarding potential future regulatory filings or approvals for, or potential future sales of, Menveo or other vaccines currently in development by Novartis. Such forward-looking statements reflect the current views of Novartis regarding future events, and involve known and unknown risks, uncertainties and other factors that may cause actual results with Menveo to be materially different from any future results, performance or achievements expressed or implied by such statements. There can be no guarantee that Menveo or any other vaccine currently in development by Novartis will be submitted or approved for any indications in any market. Nor can there be any guarantee that Menveo or any other vaccine, if approved, will achieve any particular levels of sales. In particular, management's expectations regarding Menveo could be affected by, among other things, unexpected clinical trial results, including unexpected new clinical data and unexpected additional analysis of existing clinical data; unexpected regulatory actions or delays or government regulation generally; Novartis' ability to obtain or maintain patent or other proprietary intellectual property protection; competition in general; government, industry and general public pricing pressures, and other risks and factors referred to in Novartis AG's Form 20-F on file with the U.S. Securities and Exchange Commission. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those anticipated, believed, estimated or expected. Novartis is providing the information in this press release as of this date and does not undertake any obligation to update any forward-looking statements contained in this press release as a result of new information, future events or otherwise.

About Novartis

Novartis Vaccines and Diagnostics is a division of Novartis focused on the development of preventive treatments. The division has two businesses: Novartis Vaccines and Chiron. Novartis Vaccines is the world's fifth-largest vaccines manufacturer and second-largest supplier of flu vaccines in the US. The division's products include influenza, meningococcal, pediatric and travel vaccines. Chiron, the blood testing and molecular diagnostics business, is dedicated to preventing the spread of infectious diseases through the development of novel blood-screening tools that protect the world's blood supply.

Novartis AG provides healthcare solutions that address the evolving needs of patients and societies. Focused solely on growth areas in healthcare, Novartis offers a diversified portfolio to best meet these needs: innovative medicines, cost-saving generic pharmaceuticals, preventive vaccines and diagnostic tools, and consumer health products. Novartis is the only company with leading positions in these areas. In 2007, the Group's continuing operations (excluding divestments in 2007) achieved net sales of USD 38.1 billion and net income of USD 6.5 billion. Approximately USD 6.4 billion was invested in R&D activities throughout the Group. Headquartered in Basel, Switzerland, Novartis Group companies employ approximately 98,000 full-time associates and operate in over 140 countries around the world. For more information, please visit http://www.novartis.com.

* Menactra is a registered trademark of Sanofi Pasteur.

SOURCE: Novartis Vaccines and Diagnostics