Applied Biosystems launches new genomic analysis tools

Applied Biosystems, part of Life Technologies, has launched new genomic analysis tools that will help researchers in studies that associate genetic variation with specific diseases.

These new tools, known as the MeltDoctor High-Resolution Melt (HRM) Reagents, are for research use only and are part of a PCR-based workflow that enables researchers to cost-effectively scan DNA from a variety of biological sample types to detect the smallest genetic variations among samples, Applied Biosystems said.

The MeltDoctor HRM Reagents facilitate high resolution melt, or HRM analysis, which is a technique for the detection of mutations, polymorphisms and epigenetic differences in double-stranded DNA samples. These reagents enable the characterization of variant nucleic acid sequences for advanced genomics applications such as mutation scanning, genotyping, and methylation analysis, the company added.

These tools, including software, are part of an HRM analysis workflow optimized for Applied Biosystems real-time PCR systems that is reportedly simple to perform, requiring minimal quantities of both sample and reagent to capture a significantly greater amount of detail and information for variant types, without the complexity and expense of other methods.

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