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JP Morgan Healthcare Conference

Alnylam RNAi Roundtable May 13, 2011 Agenda & Introductions Welcome Cynthia Clayton » Senior Director, Investor Relations and Corporate Communications Program Overview Akshay Vaishnaw, M.D., Ph.D. (Moderator) » Senior Vice President, Clinical Research Jared Gollob, M.D. » Senior Director, Clinical

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ALN-VSP02 Phase 1 Trial Update Demonstrating RNAi in Man Jared A. Gollob, M.D. January 4, 2011 Dana-Farber Cancer Institute Agenda LNPs and ALN-VSP02: Background Phase 1 Trial Safety Data Pharmacodynamic Data » 5’ RACE » DCE-MRI Summary 2 Lipid Nanoparticles for Systemic Delivery 3 Liver Targeting

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