According to DxS, the TheraScreen: K-RAS mutation kit detects K-RAS mutations in codons 12 and 13. The use of monoclonal antibody epidermal growth factor receptor inhibitors is not recommended for the treatment of colorectal cancer with mutations in codon 12 or 13.

Stephen Little, CEO of DxS, said: "We are very pleased to be continuing our work with Bristol-Myers Squibb and ImClone Systems to ensure K-RAS testing is available to all patients in need of treatment for metastatic colorectal cancer in the US."

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LFRP licensee ImClone Systems, a subsidiary of Eli Lilly and Company, recently announced it initiated clinical development for oncology candidate IMC-EB10, ImClone's anti-FLT3 antibody, for the treatment of acute myelogenous leukemia. Dyax received a milestone payment of $1.5 million for commencement of the Phase 1 trial which was initiated in the second quarter of 2009. Additionally, Dyax licensee MedImmune, the biologics business of AstraZeneca, announced it has advanced MEDI-547, an antibody-drug conjugate targeting EphA2 receptor for oncology indications. Dyax will receive an undisclosed milestone payment for the Phase 1 trial initiation. Dyax is eligible to receive additional future milestones associated with the development of IMC-EB10 and MEDI-547, as well as royalties on potential future net sales.

In addition to IMC-EB10, ImClone has three other antibodies in clinical development that it identified using Dyax's phage display technology. ImClone's anti-VEGFR2 antibody IMC-1121B is currently in Phase 3 development for metastatic breast cancer and gastric cancer. Additionally, Phase 3 development is expected to begin for ImClone's anti-EGFR antibody IMC-11F8 by the end of 2009 and for ImClone's anti-IGF-1R antibody IMC-A12 in either late 2009 or early 2010. The ten additional clinical-stage candidates of LFRP collaborators include three in Phase 2 trials and seven in Phase 1 trials. The LFRP also has yielded one marketed product, a purification ligand for Xyntha marketed by Wyeth Pharmaceuticals.

Overall LFRP Portfolio Also Grows

Dyax also announced the expansion of its extensive LFRP portfolio of licensees and collaborators with the signing of three new licensing agreements. These include an antibody research agreement with Novo Nordisk, an antibody therapeutic funded research collaboration with Kolltan Pharmaceuticals, and a patent license agreement with Sangamo BioSciences, Inc. To date, Dyax maintains more than 70 revenue-generating licenses and collaborations under the LFRP.

"The LFRP is a key component of our overall business strategy, and we are delighted to report on these new developments," said Gustav Christensen, President and Chief Executive Officer of Dyax. "The expansion and maturation of our licensee clinical-stage pipeline and the additions to our portfolio of LFRP licenses and collaborations continue to validate our proprietary phage display as an important drug discovery tool for the industry."

About Dyax's Phage Display

Dyax's proprietary drug discovery platform, phage display, provides an efficient means to identify compounds that interact with a wide array of therapeutic targets. Dyax's discovery capabilities have been further enhanced through automation, which has enabled the Company to evaluate a large number of molecules binding to each target. In this way, Dyax is able to rapidly identify and select a specific antibody, peptide or small protein with the desired biochemical and biological characteristics. Dyax's state-of-the-art antibody phage display libraries allows for the rapid isolation of fully human target-specific antibodies from a library of billions of unique antibodies. These extensive libraries are screened using in vitro selection strategies that are tailored to increase the yield of lead candidates with the desired therapeutic properties.

Dyax is focused on advancing novel biotherapeutics for unmet medical needs, with an emphasis on inflammatory and oncology indications.

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